BRIGHTON AI


to lower Nicotinamide N-methyltransferase (NNMT) in the body, you can increase the intake of nicotinic acid (niacin). Niacin is a form of vitamin B3 that is known to inhibit NNMT activity. Here's how you can incorporate niacin into your diet or supplement regimen:

    Diet: Include niacin-rich foods in your diet. Foods high in niacin include:
        Beef, pork, and chicken
        Fish (tuna, salmon, halibut)
        Peanuts and peanut butter
        Green vegetables (asparagus, broccoli, spinach)
        Whole grains (brown rice, whole wheat, oats)
        Yeast and yeast-based products

    Supplements: You can also take niacin supplements. Start with a low dose, such as 500 mg daily, and gradually increase to 1-2 grams per day, if well-tolerated. Keep in mind that high doses of niacin may cause side effects like flushing, itching, or gastrointestinal upset. It's best to take niacin with food to minimize these effects.

    Avoid nicotinamide: Nicotinamide (niacinamide) does not inhibit NNMT and may even increase its activity. Therefore, avoid consuming large amounts of nicotinamide or taking nicotinamide supplements if your goal is to lower NNMT levels.




GOOGLE AI


No, you cannot effectively lower Nicotinamide N-methyltransferase (NNMT) by increasing nicotinic acid (niacin) intake, and in some cases, it may even have the opposite effect. Instead, niacin increases nicotinamide (NAM), which is a substrate for NNMT; high levels of NAM would lead to increased activity of NNMT. NNMT activity is actually desired for some conditions, as its inhibition or knockdown is associated with benefits like increased energy expenditure and improved insulin sensitivity