BRIGHTON AI

No, Nicotinamide Riboside (NR) does not lower Nicotinamide N-methyltransferase (NNMT) in the body. Nicotinamide Riboside is a form of vitamin B3 that is converted to nicotinamide adenine dinucleotide (NAD+) in the body. However, neither nicotinamide (the metabolite of niacin) nor its phosphorylated form, nicotinamide mononucleotide (NMN), have been shown to inhibit NNMT activity. In fact, nicotinamide has been found to increase the activity of NNMT in some studies. To lower NNMT levels, it is recommended to increase the intake of nicotinic acid (niacin) or take nicotinic acid supplements, as mentioned in the previous response.







GOOGLE AI

No, Nicotinamide Riboside (NR) does not lower Nicotinamide N-methyltransferase (NNMT) in the body; in fact, some studies suggest NR and nicotinamide (NAM) supplementation may increase NNMT activity by providing more substrate (NAM) for the enzyme, which could potentially be related to cancer development. NNMT catalyzes the methylation of NAM, reducing its availability for NAD+ synthesis and thereby potentially affecting NAD+ levels and cellular methylation homeostasis