Low levels (deficiency) of acetylcholine play an important role in several diseases, the most common being:

    Alzheimers disease. People who have Alzheimers disease dont have enough acetylcholine in their brains.
    Lambert-Eaton myasthenic syndrome. This disorder is caused by a reduction in the release of acetylcholine from nerve cells.
    Myasthenia gravis. This is an autoimmune disorder in which theres a rapid weakening of skeletal muscles after repeated use. Some of the bodys antibodies interfere with acetylcholine receptors at the neuromuscular junction.